|
KMID : 0359319870270010009
|
|
Korean Journal of Veterinary Research
1987 Volume.27 No. 1 p.9 ~ p.17
|
|
|
BioStudy on Antiestrogenic Effects of Tamoxifen in Immature Rat Uterus
|
|
|
|
|
Abstract
|
|
|
The present study has been carried out to elucidate the antiestrogenic effects of tamoxifen in immature rat uterus. The content of DNA and protein and uterine wet weight were measured after the injections of 579 of estradiol-17β, 50㎍ of tamoxifen, a combination of both, or vehicle only subcutaneously.
The results obtained were summarized as follows :
1. DNA content in uterus was increased at 48 hours after estradiol-17β or tamoxifen injection (p<0.01).
2. The increament rate of uterine DNA content was significantly (p<0.01) lower in tamoxifen treated group than that in estradiol-17β treated group.
3. Antiestrogenic effect of tamoxifen on protein content in uterus was apparent at 72 hours after simultaneous administration of both drugs.
4. The uterine wet weight was started to increase at three hours after the injection of estradiol-17β or tamoxifen.
5. While estradiol-17β increased steadily uterine wet weight up to 138.5㎎ at 72 hours after the injection, but tamoxifen failed to increase it after 48 hours. Tamoxifen inhibited significantly (p<0.01) the effect of estradiol-17β on it thereafter.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|